To run an applications, copy the Windows application to the desktop. Then go to Applications > Accessories > Terminal
Then type in 'wine
If it looks for a .dll, you can download it from dlldump.com and copy it to the application folder before running wine.
Applications run so far:
ABC123 (kid's game)
MYOB - during installation it's looking for IE 5.5 (duh)
Cisco VTII Camera - still trying to 'make' a development driver